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Inhibition effect of bone marrow mesenchymal stem cells on T-lymphocyte proliferation through up-regulation of CD8+CD28- T cells / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 666-669, 2004.
Artículo en Chino | WPRIM | ID: wpr-347889
ABSTRACT
The aim of this study was to explore effect of CD8+CD28- T-lymphocyte in the inhibition of mesenchymal stem cells (MSC) on T-lymphocyte proliferation. T cells were harvested by using nylon column and CD8+ T cells were sorted by magnetic beads; the T-lymphocyte proliferation in the presence of PHA was evaluated by MTT; the proportion of CD8+CD28- T cells was assayed by fluorescence-activated cell sorter (FACS). The results showed that MSC inhibited T-lymphocyte proliferation and the inhibitory effect depended on the amount of MSC; the data of FACS indicated that in the CD8+ T cells co-cultured with MSC, CD8+CD28- T cells were up-regulated significantly, compared with the non-treated CD8+ T cells. In conclusion, MSC perform their immunosuppressive function by up-regulation of CD8+CD28- T cells.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fisiología / Células de la Médula Ósea / Activación de Linfocitos / Regulación hacia Arriba / Subgrupos de Linfocitos T / Antígenos CD8 / Antígenos CD28 / Alergia e Inmunología / Células Madre Mesenquimatosas Límite: Humanos Idioma: Chino Revista: Journal of Experimental Hematology Año: 2004 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fisiología / Células de la Médula Ósea / Activación de Linfocitos / Regulación hacia Arriba / Subgrupos de Linfocitos T / Antígenos CD8 / Antígenos CD28 / Alergia e Inmunología / Células Madre Mesenquimatosas Límite: Humanos Idioma: Chino Revista: Journal of Experimental Hematology Año: 2004 Tipo del documento: Artículo