Research progress of neuregulin 4 biological function / 生理学报
Acta Physiologica Sinica
; (6): 351-356, 2017.
Article
en Zh
| WPRIM
| ID: wpr-348264
Biblioteca responsable:
WPRO
ABSTRACT
Neuregulin 4 (NRG4) is a kind of protein containing epidermal growth factor (EGF)-like domains, mainly expressed and secreted by brown adipocytes. It specifically activates EGF receptor ErbB4 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) to stimulate cell proliferation, inhibit apoptosis and improve energy metabolism of cells. Increasing evidence has shown that NRG4 plays an important role in epithelial cell-related diseases, cardiovascular diseases, tumors and glycolipid metabolic diseases, and therefore it could be a potential therapeutic target of some diseases.
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Índice:
WPRIM
Asunto principal:
Fisiología
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Enfermedades Cardiovasculares
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Transducción de Señal
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Apoptosis
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Neurregulinas
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Proliferación Celular
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Metabolismo Energético
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Receptor ErbB-4
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Enfermedades Metabólicas
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Neoplasias
Límite:
Animals
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Humans
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Año:
2017
Tipo del documento:
Article