Effects of growth differentiation factor-15 (GDF-15) on neurological systems, cardiovascular diseases, and cancer progression / 生理学报
Acta Physiologica Sinica
;
(6): 109-121, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-348293
ABSTRACT
Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor beta superfamily. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. It has been suggested that GDF-15 has neurotropic effects in the nervous system. Our studies showed that GDF-15 modulated the expression of neuronal Kand Caion channels and increased the release of excitatory transmitter in the medial prefrontal cortex of mice. GDF-15 is also involved in the complex modulation of cancer and cardiovascular disease. Here, we reviewed studies involving the modulation of GDF-15 expression and its mechanisms, the primary pathological and physiological functions of GDF-15 in neurological and cardiovascular systems, and its role in cancer progression. The biological effects and the values of GDF-15 in basic research and clinical applications were also addressed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Lesiones Encefálicas
/
Canales de Calcio
/
Enfermedades Cardiovasculares
/
Canales de Potasio
/
Regulación hacia Arriba
/
Factor de Crecimiento Transformador beta
/
Corteza Prefrontal
/
Progresión de la Enfermedad
/
Factor 15 de Diferenciación de Crecimiento
/
Inflamación
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2017
Tipo del documento:
Artículo
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