Effects of moxibustion preconditioning on SOD and MDA in rats with global brain ischemia / 中国针灸

ABSTRACT

<p><b>OBJECTIVE</b>To reveal the mechanism of moxibustion preconditioning in preventive brain-protecting action.</p><p><b>METHODS</b>The rat model of global brain ischemia was made with 4-artery ligation method. 78 Wistar rats were randomly divided into 5 groups normal control group, sham-operation group, brain ischemia group, brain ischemia preconditioning group and moxibustion preconditioning group. The brain was taken 24 h, 48 h and 72 h after operation in the all groups, respectively, for determination of SOD activities by xanthine oxidase method and MDA content by thibabituric acid method.</p><p><b>RESULTS</b>The SOD activity significantly increased, especially 24 h after the moxibustion preconditioning, and the MDA content decreased significantly with a very significant difference as compared with the ischemia group(P<0.01).</p><p><b>CONCLUSION</b>Moxibustion preconditioning exerts the protective action on the brain tissue of ischemia and anoxia through increasing the endogenous anti-oxidase activity.</p>