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Association between pancreatic cancer risk and the interaction of U2AF65 gene polymorphisms and smoking / 中华流行病学杂志
Chinese Journal of Epidemiology ; (12): 710-713, 2014.
Artículo en Chino | WPRIM | ID: wpr-348588
ABSTRACT
<p><b>OBJECTIVE</b>To determine the association between U2 small nuclear ribonucleoprotein auxiliary factor 35/65 (U2AF35 and U2AF65) and pancreatic cancer (PC).</p><p><b>METHODS</b>A two-stage analysis case-control study was conducted. Four candidate tag single nucleotide polymorphisms (tagSNPs) were genotyped by Taqman Openarray assay in a screening population living in Central China (298 PC cases and 525 controls). Thereafter, rs310445 in U2AF65 was genotyped by TaqMan real-time polymerase chain reaction (RT-PCR) in a validation Chinese Han population from Beijing (413 cases and 557 controls).</p><p><b>RESULTS</b>rs310445 in U2AF65 gene was significantly associated with PC in both screened population and combined population. Subjects with C allele had a higher risk of PC compared to those with the TT genotype, with OR of 1.31 (95%CI1.07-1.60, P = 0.010) for the combined population. A synergic effect of smoking and C allele of rs310445 was also observed in the combined population, with Synergic Index of 2.08 (95% CI1.37-2.78) in the combined population.</p><p><b>CONCLUSION</b>Our findings suggested the interaction between smoking and U2AF65 might play a role in PC. These findings should be confirmed by further independently large-scale population studies.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Pancreáticas / Ribonucleoproteínas / Proteínas Nucleares / Fumar / Estudios de Casos y Controles / Factores de Riesgo / Polimorfismo de Nucleótido Simple / Factor de Empalme U2AF / Genética / Genotipo Tipo de estudio: Estudio de etiología / Estudio observacional / Factores de riesgo Límite: Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Epidemiology Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Pancreáticas / Ribonucleoproteínas / Proteínas Nucleares / Fumar / Estudios de Casos y Controles / Factores de Riesgo / Polimorfismo de Nucleótido Simple / Factor de Empalme U2AF / Genética / Genotipo Tipo de estudio: Estudio de etiología / Estudio observacional / Factores de riesgo Límite: Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Epidemiology Año: 2014 Tipo del documento: Artículo