Association of TNF-α-308 polymorphisms with risk of chronic HBV infection in the Chinese population: a Meta-analysis / 中华流行病学杂志

ABSTRACT

Objective To explore the association between TNF-α gene 308 locus polymorphism and the risk of chronic HBV infection in Chinese population.Methods PubMed,Embase,CNKI and SinoMed database were searched for relevant articles published from January 2001 to May 2013.Case-control studies on TNF-α-308 polymorphism with chronic HBV infection in Chinese population were gathered with meta-analysis applied for calculation of pooled OR value (with 95％CI) after data abstraction.Results Eleven case-control studies for the TNF-α-308 polymorphism with a total of 1 872 cases and 1 471 controls were included.Results from the overall meta-analysis indicated that-308A allele had a significant decreased risk of chronic HBV infection (A vs.GOR=0.579,95％CI0.422-0.794; GA vs.GGOR=0.525,95％CI0.325-0.847; AA vs.GGOR=0.301,95％CI0.125-0.720; GA+AA vs.GGOR=0.490,95％CI0.309-0.777; AA vs.GA+GGOR=0.542,95％CI0.394-0.746).In subgroup analyses by region,a significantly decreased risk seemed associated with-308A allele in population from northern China.When stratified by case type,control type and genotyping methods,there apppeared no significant association between TNF-α-308A allele and chronic HBV infection in the studies when spontaneously recovered one' s were used as controls and PCR used as its methodology.Conclusion TNF-α-308A allele seemed a protective factor for chronic HBV infection in the Chinese population.