Advances in the structure-activity relationship study of natural flavonoids and its derivatives / 药学学报
Acta Pharmaceutica Sinica
; (12): 622-630, 2011.
Article
en Zh
| WPRIM
| ID: wpr-348909
Biblioteca responsable:
WPRO
ABSTRACT
Flavonoids are a large class of compounds widely distributed in nature. Many pharmacological activities of flavonoids have been reported such as anti-cancer, antioxidant, anti-inflammatory, hepatoprotective, antithrombotic, vasodilator, antiviral, antibacterial, antiallergic, and so on. In recent years, domestic and foreign research groups choose natural flavonoids and optimize their chemical structures in order to develop a number of new derivatives with stronger pharmacological activities. As part of the mechanisms are not clear, we need to strengthen in-depth research in the SAR (structure-activity relationship) study for targeted and efficient structure optimization. This paper systematically summarize current researches in the SAR studies of flavonoids and their derivatives, which can serve as a reference for synthesizing new flavonoid derivatives.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Antivirales
/
Farmacología
/
Plantas Medicinales
/
Relación Estructura-Actividad
/
Vasodilatadores
/
Flavonoides
/
Química
/
Antisepsia
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Fibrinolíticos
/
Antiinflamatorios
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2011
Tipo del documento:
Article