Synthesis of ferulic acid derivatives and their inhibitory effect on platelet aggregation / 药学学报
Acta Pharmaceutica Sinica
;
(12): 305-310, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-348960
ABSTRACT
Ferulic acid, an useful compound of Chinese traditional medicine, was used as leading compound. Six ferulic acid derivatives were designed and synthesized based on bioisosterism. Their structures were characterized by IR, 1H NMR, 13C NMR and mass spectra. In vivo experiment showed that ferulic acid derivatives had good inhibitory effects on adenosine diphosphate (ADP) induced platelet aggregation, which were significantly higher than that of Ozagrel.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Relación Estructura-Actividad
/
Inhibidores de Agregación Plaquetaria
/
Distribución Aleatoria
/
Química
/
Agregación Plaquetaria
/
Ácidos Cumáricos
Límite:
Animales
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2011
Tipo del documento:
Artículo
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