Existing problems and strategies in liposome-mediated nucleic acid delivery / 药学学报
Acta Pharmaceutica Sinica
;
(12): 261-268, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-348967
ABSTRACT
Liposome-mediated nucleic acid delivery has been a focus recently, but in the course of delivering nucleic acid, some hurdles seriously limit the nucleic acid exerting treatment effect. This review refers to a series of problems such as low blood stability, reticuloendothelial system absorption, the lower targeting of liposome and the restriction of endosomal escape which are suffered in liposome-mediated nucleic acid delivery; and gives a detail introduction of strategies such as PEGylation, ligand modification, photochemical internalization, the application of degradation liposome and membrane-lytic peptide, to overcome those problems.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polietilenglicoles
/
Polímeros
/
Sistema Mononuclear Fagocítico
/
Farmacocinética
/
Ácidos Nucleicos
/
Química
/
Nanopartículas
/
Procesos Fotoquímicos
/
Liposomas
/
Metabolismo
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2011
Tipo del documento:
Artículo
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