Determination of protein binding rate of oleanolic acid in human plasma and serum albumin / 药学学报
Acta Pharmaceutica Sinica
;
(12): 243-246, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-348970
ABSTRACT
A LC-MS method was established for the determination of the protein binding rates of oleanolic acid in human plasma and serum albumin. The equilibrium dialysis combined with LC-MS to determine the total concentration in plasma and free drug concentration of oleanolic acid was carried out. The human plasma protein binding rates of oleanolic acid at three concentrations were 79.6%, 81.9% and 63.3%, respectively. The human serum albumin protein binding rates of oleanolic acid at three concentrations were 53.5%, 56.6% and 47.7%, respectively. The method is shown to be simple, accurate, sensitive and specific for the determination of biological samples. The protein binding rates in human plasma and serum albumin were of high strength.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ácido Oleanólico
/
Unión Proteica
/
Espectrometría de Masas
/
Sangre
/
Albúmina Sérica
/
Cromatografía Liquida
/
Sensibilidad y Especificidad
/
Diálisis
/
Metabolismo
/
Métodos
Tipo de estudio:
Estudio diagnóstico
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2011
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS