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Study of a novel compound 2460A with activities produced by fungus / 药学学报
Acta Pharmaceutica Sinica ; (12): 165-169, 2011.
Artículo en Chino | WPRIM | ID: wpr-348981
ABSTRACT
With IL-6R as target, a new compound 2460A was identified from fungus using HTS screening model. The taxonomics of the produced strain was confirmed to be Trichoderma hazianum rifai after sequencing analysis of rDNA-ITS (internal transcribed spacer). Results showed that this compound has a binding activity on IL-6R competed with IL-6, thus it is a new ligand of IL-6R originating from microbe. With MTT assay, the anti-tumor activities of 2460A were demonstrated on CM126 and HT-29 cell lines separately, the IC50 are 2.17 x 10(-5) mol x L(-1) and 1.8 x 10(-5) mol x L(-1) respectively. The compound affected lightly the HT-29 cell cycle at S phase. Studies for the anti-tumor activity of 2460A in vivo are in progress in our lab.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Farmacología / Trichoderma / Unión Competitiva / Ciclo Celular / Química / Interleucina-6 / Células HT29 / Neoplasias de la Médula Ósea / Receptores de Interleucina-6 Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Farmacología / Trichoderma / Unión Competitiva / Ciclo Celular / Química / Interleucina-6 / Células HT29 / Neoplasias de la Médula Ósea / Receptores de Interleucina-6 Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2011 Tipo del documento: Artículo