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Targeted therapies for patients with advanced NSCLC harboring wild-type EGFR: what's new and what's enough / 癌症
Chinese Journal of Cancer ; (12): 310-319, 2015.
Artículo en Inglés | WPRIM | ID: wpr-349587
ABSTRACT
Historically, non-small cell lung cancer (NSCLC) is divided into squamous and nonsquamous subtypes based on histologic features. With a growing number of oncogenic drivers being identified in squamous and nonsquamous NSCLC, this malignancy has been recently divided into several distinct subtypes according to the specific molecular alterations. This new paradigm has substantially highlighted the treatment of advanced NSCLC, shifting it from standard chemotherapy according to specific histologic subtypes to targeted therapy according to specific oncogenic drivers. The application of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in NSCLC patients harboring activating EGFR mutations has been a representative model of precise medicine in the treatment of NSCLC. As the role of EGFR-TKIs in routine management of patients with advanced NSCLC has been well established, this review provides an overview of alternative targeted therapy in the treatment of NSCLC, including EGFR-TKIs for patients with wild-type EGFR NSCLC, as well as other targeted agents either clinical available or in early- to late-stage development.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Receptores ErbB / Neoplasias Pulmonares / Mutación / Antineoplásicos Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Chinese Journal of Cancer Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Receptores ErbB / Neoplasias Pulmonares / Mutación / Antineoplásicos Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Chinese Journal of Cancer Año: 2015 Tipo del documento: Artículo