Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins / 癌症
Chinese Journal of Cancer
;
(12): 325-334, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-349588
ABSTRACT
Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-viral and anti-tumor activities. Multiple RIPs are known to inhibit tumor cell proliferation through inducing apoptosis in a variety of cancers, such as breast cancer, leukemia/lymphoma, and hepatoma. This review focuses on the anti-tumor activities of RIPs and their apoptotic effects through three closely related pathways mitochondrial, death receptor, and endoplasmic reticulum pathways.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteínas de Plantas
/
Ribosomas
/
Apoptosis
/
Retículo Endoplásmico
/
Receptores de Muerte Celular
/
Proteínas Inactivadoras de Ribosomas
/
Mitocondrias
/
Antineoplásicos
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Cancer
Año:
2015
Tipo del documento:
Artículo
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