Analysis of the changes in bacterial types and drug sensitivity profiles of mycobacterial strains in Guangzhou over the last twelve years / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 26-29, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-349885
ABSTRACT
<p><b>OBJECTIVE</b>To improve evidence-based care in the management of tuberculosis, we retrospectively analyzed the bacterial types and drug sensitivity test results of mycobacteria in Guangzhou over the past twelve years (from July 1998 to March 2010).</p><p><b>METHODS</b>Over these twelve years, a total of 14 095 mycobacterial strains isolated from different samples were subjected to type identification and drug sensitivity tests according to the Standard Protocols of Laboratory Diagnostics for Tuberculosis by the Chinese Antituberculosis Association. Chi-square test was performed for statistical analyses for comparisons between groups.</p><p><b>RESULTS</b>Of 14 095 strains of mycobacteria isolated, 10 844 strains (76.84%) were MTB, and 3251 strains (23.16%) were non-tuberculosis mycobacteria (NTM). Compared with the result of the fourth national survey of tuberculosis epidemiology, which showed 11.1% of NTM, the one of our study was significantly different (χ(2) = 69.79, P < 0.001). Drug sensitivity tests of MTB showed tolerance rates of 28.99% (2729/9413), 21.75% (2047/9413), 17.45% (1643/9413) and 11.53% (1085/9413) against isoniazid, rifampin, streptomycin and ethambutol, respectively.</p><p><b>CONCLUSION</b>An increasing trend was observed in MTB drug tolerance against streptomycin, rifampin and isoniazid, whereas more and more NTM strains were isolated in recent years. These findings are worthy of note for clinicians.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Tuberculosis
/
Pruebas de Sensibilidad Microbiana
/
China
/
Epidemiología
/
Técnicas de Tipificación Bacteriana
/
Clasificación
/
Farmacorresistencia Bacteriana
/
Microbiología
/
Mycobacterium
Tipo de estudio:
Estudio diagnóstico
/
Guía de Práctica Clínica
/
Estudio pronóstico
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Chinese Journal of Preventive Medicine
Año:
2011
Tipo del documento:
Artículo
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