Association of aldosterone synthase (CYP11B2) gene -344T/C polymorphism with essential hypertension in Mongolian nationality / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 800-805, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-349939
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between the -344T/C polymorphism of aldosterone synthase (CYP11B2) gene and essential hypertension in Chinese Mongolian population.</p><p><b>METHODS</b>By cluster-sampling method, a total of 1575 Mongolian people in Tongliao city of Inner Mongolia were included in this study. And 417 subjects were normotension, 596 subjects were prehypertension and 562 subjects were essential hypertension. A survey was conducted to collect data by personal interview using a standard questionnaire, meanwhile fasting blood samples were drawn. Height, weight, waist circumference, blood pressure, blood-fat indexes and fasting plasma glucose were measured. The variant genotypes of CYP11B2 were identified by PCR assays. The relationship between the -344T/C polymorphism of CYP11B2 gene and essential hypertension were analyzed by multinomial logistic regression model.</p><p><b>RESULTS</b>Crude prevalence of prehypertension among Mongolian people was 37.84% (596/1575) and hypertension was 35.68% (562/1575). The age-standardized prevalence of prehypertension was 38.57% and hypertension was 31.53%. The frequency of the T and C allele was 0.66 (481/728) and 0.34 (247/728) for normotension group, 0.69 (696/1042) and 0.33 (346/1042) for prehypertension group, 0.71 (706/998) and 0.29 (292/998) for hypertension group. The multiple logistic models showed CYP11B2 variant genotypes were associated with prehypertension (TT/CC, OR = 1.33, 95%CI 0.87 - 2.01; TC/CC, OR = 1.74, 95%CI 1.13 - 2.67; TC + TT/CC, OR = 1.49, 95%CI 1.01 - 2.22); CYP11B2 variant genotypes were associated with hypertension (TT/CC, OR = 1.70, 95%CI 1.07 - 2.70; TC/CC, OR = 1.59, 95%CI 0.98 - 2.50; TC + TT/CC, OR = 1.66, 95%CI 1.06 - 2.58).</p><p><b>CONCLUSION</b>CYP11B2 gene -344T/C polymorphism were associated with essential hypertension in Chinese Mongolian population.</p>
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Presión Sanguínea
/
China
/
Epidemiología
/
Citocromo P-450 CYP11B2
/
Polimorfismo de Nucleótido Simple
/
Pueblo Asiatico
/
Alelos
/
Frecuencia de los Genes
/
Genética
/
Genotipo
Tipo de estudio:
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Chinese Journal of Preventive Medicine
Año:
2010
Tipo del documento:
Artículo
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