Histologic and ultrastructural studies of the patient died of highly pathogenic H5N1 avian influenza virus infection in China / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 150-154, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-349951
ABSTRACT
<p><b>OBJECTIVE</b>To explore histopathologic and ultrastructural characteristics of human avian influenza (AI) infection and related etiological pathogenesis.</p><p><b>METHODS</b>Postmortem lung and heart samples were collected from the patient who died of avian influenza virus infection on November 29, 2003 in China. Light and electron microscopy, immunohistochemistry and histochemistry were used to investigate the pathological changes.</p><p><b>RESULTS</b>The main pathological findings included extensive pulmonary consolidation, hemorrhage, pulmonary edema and local hemorrhagic infarct. The lamina of alveoli and bronchioles were abundantly filled with protein-rich fluid, erythrocytes, fibrin and cell debris admixed with many neutrophilis, macrophages, lymphocytes and a few of monokaryon and multinuclear giant cells. Hyaline membranes were formed. Local pulmonary tissues were heavily damaged by hemorrhage and necrosis. Alveolar septum was disintegrated. Mesenchymal edema with a few of macrophages infiltration of heart was found. Electron microscopy showed the avian influenza A virus-like particles (type C and type A) of 80 - 120 nm diameter and envelopes in the cytoplasm of pneumocytes and endothelial cells.</p><p><b>CONCLUSIONS</b>Fatal pneumonia associated with highly pathogenic avian influenza A virus (H5N1) infection leads to extensive pulmonary consolidation, edema and marked hemorrhagic necrosis and inflammation. Electron microscopy can identify avian influenza A virus-like particles. The findings may offer an important theoretical basis for clinical diagnosis and treatment.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Virus de la Influenza A
/
Patología
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Autopsia
/
Cirugía General
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Virología
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Virulencia
/
Aves
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Diagnóstico por Imagen
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Microscopía Electrónica
/
China
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Animales
/
Humanos
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Chinese Journal of Pathology
Año:
2008
Tipo del documento:
Artículo
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