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Linkage disequilibrium analysis of the single nucleotide polymorphisms in the PRKCZ gene / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 474-480, 2002.
Artículo en Chino | WPRIM | ID: wpr-350081
ABSTRACT
<p><b>OBJECTIVE</b>To search for the disease-associated haplotype in the PRKCZ gene, a susceptibility gene for type 2 diabetes in Han population of North China, by case-control study and linkage disequilibrium (LD) analysis using single nucleotide polymorphisms (SNPs).</p><p><b>METHODS</b>SNPs located in the PRKCZ gene were chosen from public SNP domain by bioinformatic methods and single base extension (SBE) method was used to genotype the loci in 173 sporadic type 2 diabetes patients and 152 normal individuals to perform case-control study and LD analysis. Haplotype block were constructed in these populations.</p><p><b>RESULTS</b>Several SNPs in the PRKCZ gene were found to be associated with the disease. The SNPs formed different haplotype block pattern in case and control groups. The frequencies of the haplotypes formed by 5 SNPs were statistically different between the two groups.</p><p><b>CONCLUSION</b>The haplotype formed by 5 SNPs in the PRKCZ gene may be associated with type 2 diabetes in Han population of China, which is confirmed from statistics to be a susceptibility gene for the disease.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Haplotipos / Proteína Quinasa C / Etnicidad / Estudios de Casos y Controles / Desequilibrio de Ligamiento / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Pueblo Asiatico / Diabetes Mellitus Tipo 2 / Alelos Tipo de estudio: Estudio observacional / Factores de riesgo Límite: Humanos Idioma: Chino Revista: Acta Academiae Medicinae Sinicae Año: 2002 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Haplotipos / Proteína Quinasa C / Etnicidad / Estudios de Casos y Controles / Desequilibrio de Ligamiento / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Pueblo Asiatico / Diabetes Mellitus Tipo 2 / Alelos Tipo de estudio: Estudio observacional / Factores de riesgo Límite: Humanos Idioma: Chino Revista: Acta Academiae Medicinae Sinicae Año: 2002 Tipo del documento: Artículo