Vitamin K and osteoporosis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 346-349, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-350094
ABSTRACT
There is a closely relationship between vitamin K and osteoporosis. As a cofactor for carboxylase activity, vitamin K can facilitate the conversion of glutamyl to gamma-carboxyglutamyl residues and influence the synthesis and excretion of gamma-carboxylation of osteocalcin to increase the formation of bone. Vitamin K can also effectively inhibit the absorption of bone mass. Besides, there are increasing evidences that vitamin K can effect the synthesis and excretion of nephrocalcin and interlukin-1,6 that can regulate calcium balance and bone metabolism. Meanwhile, there is a consistent line of evidence in human epidemiologic and intervention studies that clearly demonstrate that vitamin K can not only increase bone mineral density in osteoporotic people, but also reduce fracture rates to improve bony health. However more researches are required before vitamin K is widely applied in prevention and treatment of osteoporosis. The American Medical Association recently has increased the dietary reference intakes of vitamin K to 90 mg/d for females and 120 mg/d for males.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteoporosis
/
Farmacología
/
Vitamina K
/
Densidad Ósea
/
Osteocalcina
/
Usos Terapéuticos
/
Quimioterapia
/
Metabolismo
/
Necesidades Nutricionales
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2003
Tipo del documento:
Artículo
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