The effect of 1,25(OH)D3 deficiency in the secondary dentin formation and mineralization and caries of the mice / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 599-606, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-350274
ABSTRACT
<p><b>OBJECTIVE</b>To determine the role of 1,25(OH)2D3 on the secondary dentin formation and mineralization of the mice.</p><p><b>METHODS</b>The differences of the mandible mineralization between the wild-type and 1-alpha-hydroxylase gene knockout mice at 6 weeks old were assessed by hematoxylin-eosin (HE) staining, immunohistochemistry, alkaline phosphatase (ALP) histochemistry staining.</p><p><b>RESULTS</b>The ratio of caries were increased significantly, while the secondary dentin was reduced significantly, the deposition of type I collagen and osteocalcin on the secondary dentin of occlusion surface was decreased significantly, but the deposition of the Biglycan on the dentin was increased significantly, the active of ALP on the odontoblasts were reduced significantly in 1-alpha-hydroxylase gene knockout mice compared to that in the wild-type littermates.</p><p><b>CONCLUSION</b>1,25(OH)2D3 deficiency lead to a defect in the secondary dentin formation and mineralization and caries of the mice.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteocalcina
/
Dentina
/
Dentina Secundaria
/
Mandíbula
Límite:
Animales
Idioma:
Chino
Revista:
West China Journal of Stomatology
Año:
2010
Tipo del documento:
Artículo
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