Advances in studies on toxicity of aconite / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1126-1129, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-350647
ABSTRACT
Aconite has the efficacy of reviving yang for resuscitation, dispelling cold and relieving pain, which is widely used in clinic, and shows unique efficacy in treating severe diseases. However, aconite has great toxicity, with obvious cardio-toxicity and neurotoxicity. Its toxicological mechanism main shows in the effect on voltage-dependent sodium channels, release of neurotransmitters and changes in receptors, promotion of lipid peroxidation and cell apoptosis in heart, liver and other tissues. Aconite works to reduce toxicity mainly through compatibility and processing. Besides traditional processing methods, many new modern processing techniques could also help achieve the objectives of detoxification and efficacy enhancement. In order to further develop the medicinal value of aconite and reduce its side effect in clinical application, this article gives comprehensive comments on aconite's toxicity characteristics, mechanism and detoxification methods on the basis of relevant reports for aconite's toxicity and the author's experimental studies.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Medicamentos Herbarios Chinos
/
Extractos Vegetales
/
Química
/
Química Farmacéutica
/
Aconitum
/
Composición de Medicamentos
/
Toxicidad
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2013
Tipo del documento:
Artículo
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