Chemoinformatics study on antibacterial activity of traditional Chinese medicine compounds / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 777-780, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-350687
ABSTRACT
<p><b>OBJECTIVE</b>The structure-activity relationship between traditional Chinese medicine (TCM) compounds and antibacterial activity was studied by chemoinformatics approach.</p><p><b>METHOD</b>Cytoscape and its plug-in ChemViz were applied to compute the 2D chemical structure similarity and topological parameter TPSA (topological molecular polar surface area), which measures cell permeability of chemicals, between TCM compounds and clinical antibacterials. The overall degree of structure similarity was then calculated and represented by E-value for the eight categories of TCM compounds and the known antibacterials.</p><p><b>RESULT</b>Our results indicated that flavonoids showed good structural similarity with antibacterials and appropriate cell permeability, compared with those of the TCM compounds of the other categories. As flavonoids were featured by good drug safety, it suggested that they can be regarded as the preferred lead compounds skeleton structure source for further antibacterials synthesis.</p><p><b>CONCLUSION</b>The application of chemoinformatics helps explore the structure-activity relationship between TCM compounds and the antibacterial activity and search for suitable antibacterial lead compounds skeleton structure source.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Relación Estructura-Actividad
/
Programas Informáticos
/
Química
/
Estadística como Asunto
/
Informática
/
Medicina Tradicional China
/
Métodos
/
Antibacterianos
Tipo de estudio:
Estudio diagnóstico
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2013
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS