Study on efficacy and mechanism of weiyangning pills against experimental gastric ulcer / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 736-739, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-350695
ABSTRACT
<p><b>OBJECTIVE</b>To study the efficacy and mechanism of Weiyangning pills against experimental gastric ulcer.</p><p><b>METHOD</b>The gastric ulcer model were established by acetic acid, water-immersion stress, aspirin induction, pyloric ligation in rats, in order to observe the effect of Weiyangning pills against experimental gastric ulcer and study its effect on the content of nitric oxide (NO) and epidermal growth factor (EGF), gastric mucosal blood flow, the content of PGE2, gastric secretion, gastric acid content and the activity of pepsin.</p><p><b>RESULT</b>Weiyangning pills markedly reduced index of gastric ulcers of various types, increased the content of NO, EGF, PGE2 and gastric mucosal blood flow, inhibited gastric secretion and gastric acid content, and decreased the activity of pepsin.</p><p><b>CONCLUSION</b>Weiyangning pills has a significant effect against experimental gastric ulcer, which is related to the reduction of gastric mucosa damage factors (gastric acid and pepsin) and the increase in gastric mucosa's function as a barrier and its recovery effects, such as NO, EGF, PGE2 and gastric mucosal blood flow.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Flujo Sanguíneo Regional
/
Úlcera Gástrica
/
Medicamentos Herbarios Chinos
/
Dinoprostona
/
Aspirina
/
Ratas Sprague-Dawley
/
Ácido Acético
/
Secreciones Corporales
/
Usos Terapéuticos
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2013
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS