Pharmacodynamic study of Relinqing granules on bacterial pyelonephritis model in rats / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the effects of Relinqing granules (powder of Polygonum capitatum extract) on the bacterial pyelonephritis model in rats.</p><p><b>METHOD</b>The rat bacterial pyelonephritis model was induced by injecting the escherichia coli ATCC-25922 into kidney parenchyma. The rats were divided ramdamly into Relinqing groups(52.32, 26.16 g x kg(-1)), norflorin group (0.03 g x kg(-1)), model group and normal control group, and were given experimental drugs by gastrogavage. The contents of leucocytes (WBC), occult bloo (BLD), glucose (GLU), protein (PRO), ketones, bilirubin and urobilinagen in urine were determined.</p><p><b>RESULT</b>As compared with the model group, Relinqing granules 6.0 g x kg(-1) (crude drug 52.32 g x kg(-1)) could decrease significantly the contents of WBC and BLD in urine and, however, had no markedly effects on the other biochemical parameters of urine.</p><p><b>CONCLUSION</b>Relinqqing granule has significant effects of decreasing urine WBC and BLD on the bacterial pyolonephritis in rats.</p>