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Study on solid dispersion of precipitated calcium carbonate-based oleanolic acid / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1935-1938, 2015.
Artículo en Chino | WPRIM | ID: wpr-351236
ABSTRACT
Oleanolic acid-precipitated calcium carbonate solid dispersion was prepared by using solvent evaporation method. The microscopic structure and physicochemical properties of solid dispersion were analyzed using differential scanning calorimetry and scanning electron microscopy (SEM). And its in vitro release also was investigated. The properties of the precipitated calcium carbonate was studied which was as a carrier of oleanolic acid solid dispersion. Differential scanning calorimetry analysis suggested that oleanolic acid may be present in solid dispersion as amorphous substance. The in vitro release determination results of oleanolic acid-precipitated calcium carbonate (1 5) solid dispersion showed accumulated dissolution rate of.oleanolic acid was up to 90% at 45 min. Accelerating experiment showed that content and in vitro dissolution of oleanolic acid solid dispersion did not change after storing over 6 months. The results indicated that in vitro dissolution of oleanolic acid was improved greatly by the solid dispersion with precipitated calcium carbonate as a carrier. The solid dispersion is a stabilizing system which has actual applied value.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Ácido Oleanólico / Solubilidad / Carbonato de Calcio / Rastreo Diferencial de Calorimetría / Portadores de Fármacos / Extractos Vegetales / Microscopía Electrónica de Rastreo / Química / Química Farmacéutica / Estabilidad de Medicamentos Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Ácido Oleanólico / Solubilidad / Carbonato de Calcio / Rastreo Diferencial de Calorimetría / Portadores de Fármacos / Extractos Vegetales / Microscopía Electrónica de Rastreo / Química / Química Farmacéutica / Estabilidad de Medicamentos Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2015 Tipo del documento: Artículo