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Changes in serum YKL-40 level and humoral immune function and their significance in children with recurrent pneumonia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 425-429, 2017.
Artículo en Chino | WPRIM | ID: wpr-351330
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the changes in serum YKL-40 level and humoral immune function and their significance in children with recurrent pneumonia.</p><p><b>METHODS</b>Blood samples were collected from 30 children with recurrent pneumonia (recurrent pneumonia group), 30 children with acute pneumonia (acute pneumonia group), and 30 healthy children (control group). Serum YKL-40 levels were measured by enzyme-linked immunosorbent assay. The correlation between serum YKL-40 level and laboratory indices related to humoral immune function was analyzed. The receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of serum YKL-40 level for recurrent pneumonia.</p><p><b>RESULTS</b>The recurrent pneumonia group had a significantly higher serum YKL-40 level than the acute pneumonia and control groups (P<0.05). The acute pneumonia group had a significantly higher serum YKL-40 level than the control group (P<0.05). Serum levels of IgG and complement 4 in the recurrent pneumonia group were significantly lower than in the acute pneumonia group (P<0.05). Serum YKL-40 level was negatively correlated with serum IgG level (r=-0.309, P=0.047) and serum complement 4 level (r=-0.324, P=0.039). The area under the ROC curve of serum YKL-40 level for diagnosing recurrent pneumonia was 0.958 (95%CI 0.921-0.994).</p><p><b>CONCLUSIONS</b>Humoral immune function is low in children with recurrent pneumonia. Serum YKL-40 may be involved in the occurrence of recurrent pneumonia and can be used as a reference index for diagnosing recurrent pneumonia.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neumonía / Recurrencia / Sangre / Complemento C4 / Inmunoglobulina G / Alergia e Inmunología / Inmunidad Humoral / Proteína 1 Similar a Quitinasa-3 Tipo de estudio: Estudio pronóstico Límite: Child, preschool / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Contemporary Pediatrics Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neumonía / Recurrencia / Sangre / Complemento C4 / Inmunoglobulina G / Alergia e Inmunología / Inmunidad Humoral / Proteína 1 Similar a Quitinasa-3 Tipo de estudio: Estudio pronóstico Límite: Child, preschool / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Contemporary Pediatrics Año: 2017 Tipo del documento: Artículo