Analysis of the clinical characteristics of Kartagener syndrome in Chinese and foreign children / 中华儿科杂志
Chinese Journal of Pediatrics
;
(12): 850-854, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-351466
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the clinical characteristic of Kartagener syndrome in Chinese and foreign children.</p><p><b>METHOD</b>Four cases of Kartagener syndrome diagnosed in our hospital were analyzed with literature review. The differences between Chinese and foreign children in clinical manifestations and diagnosis were compared.</p><p><b>RESULT</b>All of the cases had the following clinical manifestations recurrent productive cough, nasosinusitis, dextrocardia, total situs inversus and bronchiectasia. Situs inversus of the airway structure was visible under the bronchoscope, and electron microscopy of the respiratory mucosa showed an abnormal ciliary ultrastructure. By using "Kartagener syndrome" and "child" as the key words, reports on 55 Chinese cases and 61 foreign cases in children were retrieved from CNKI and PubMed databases. The average age of diagnosis was 9.16 ± 3.67 years in China, which was significantly later than 7.07 ± 4.92 years in foreign countries (t=2.642, P<0.01). The main clinical manifestations were recurrent productive cough, nasosinusitis or rhinopolyp, recurrent pulmonary infection, recurrent wheezing and otitis media. Sinus imaging showed maxillary sinusitis. Dextrocardia, total situs inversus and bronchiectasia were found on thoracic and abdominal CT. The ciliary ultrastructural analysis showed shorter and missing dynein arm (6/6 cases in China and 25/27 cases in foreign) .</p><p><b>CONCLUSION</b>The clinical manifestations are recurrent upper and lower respiratory tract infection combined with dextrocardia or other situs inversus in both China and other countries. The diagnosis abroad relied more on abnormal ciliary ultrastructure observed under electron microscopy, but in China mainly relied on its typical clinical manifestations.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Infecciones del Sistema Respiratorio
/
Situs Inversus
/
Microscopía Electrónica
/
China
/
Síndrome de Kartagener
/
Cilios
/
Pueblo Asiatico
/
Diagnóstico
/
Etnología
Tipo de estudio:
Estudio diagnóstico
Límite:
Niño
/
Humanos
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Chinese Journal of Pediatrics
Año:
2015
Tipo del documento:
Artículo
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