Comparative genomic reconstruction of regulatory and metabolic networks in bacteria / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1349-1356, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-351587
ABSTRACT
A large and growing number of complete genomes from diverse species open tremendous opportunities for getting deep insights into cell metabolism. This increased understanding strongly supports engineering of cell metabolism for microbial production. In spite of the recent progress, a large fraction of genes in most of the available genomes remain incorrectly or imprecisely annotated. In this paper we review some of the new comparative genomics techniques used to reconstruct regulatory and metabolic networks from genomic data, reveal gaps in current knowledge, and identify previously uncharacterized genes. The application will be discussed by using a recent example-reconstruction of xylose utilization pathway in Clostridium acetobutylicum.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Bacterias
/
Xilosa
/
Ingeniería Genética
/
Genoma Bacteriano
/
Genómica
/
Clostridium acetobutylicum
/
Redes y Vías Metabólicas
/
Hibridación Genómica Comparativa
/
Genética
Idioma:
Chino
Revista:
Chinese Journal of Biotechnology
Año:
2010
Tipo del documento:
Artículo
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