Current situation and progression of induced pluripotent stem cells in treating spinal cord injury / 中国骨伤

ABSTRACT

Spinal cord injury is a difficult medical problem and current therapeutic methods could not obtain satisfactory results. Recent 20 years, stem cell technology developed rapidly, embryonic stem cells and adult stem cells were used for treating neurological disease and nerve injury of animal models and the clinical results were confirmed. It provided a new prospect for the treatment of nerve injury at the cellular level. However,due to technical and ethical problems, it is difficult to obtain the appropriate cells that can be applied to the human being. Recently, induced pluripotent stem cells were developed as a new method for the treatment of spinal cord injuries by the autologous transplantation. Starting from this work, the purpose of this review is to assess the differentiate ability of induced pluripotent stem cells into neurocyte and review the latest developments in this area.