Bioactive isomalabaricane triterpenes isolated from marine sponge Rhabdastrella aff. distincta / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the chemical constituents of the marine sponge Rhabdastrella aff. distincta.</p><p><b>METHOD</b>Compounds were obtained by normal phase silica gel, Sephadex LH-20, reverse phase chromatogrophy and methylation method. These structures were determined on the basis of IR, MS, NMR spectral analysis.</p><p><b>RESULT</b>Eight compounds were isolated from bioactive CH3Cl fraction and identified as geoditin A (1), geoditin B (2), stellettin A (5), stellettin B (4), stellettin C (3), stellettinE (7), rhabdastrellic acid A (8) and the methyl ester of stellettin E (6).</p><p><b>CONCLUSION</b>All these compounds were obtained from this species for the first time.</p>