Progress of studies on enhancing efficiency of gene transfection into hematopoietic cells with the adenoviral vector--review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 383-386, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-352058
ABSTRACT
Recombinant adenoviral vectors have been widely applied for the basic research and clinical trials of gene therapy. However, the inability of adenovirus to infect hematopoietic cells which lack the specific adenovirus receptors-coxsackie virus and adenovirus receptor (CAR) represents an important limitation in therapeutic applications. This limitation may be overcome by several approaches including modification of adenovirus vector and improvement of the susceptibility of hematopoietic cells. The current progresses in this field were summarized.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Receptores Virales
/
Células Madre Hematopoyéticas
/
Transfección
/
Terapia Genética
/
Adenoviridae
/
Proteína de la Membrana Similar al Receptor de Coxsackie y Adenovirus
/
Genética
/
Metabolismo
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2004
Tipo del documento:
Artículo
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