Your browser doesn't support javascript.
loading
Significance of detecting platelet associated antibody and platelet membrane glycoprotein for diagnosis of immune thrombocytopenia / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 224-227, 2004.
Artículo en Chino | WPRIM | ID: wpr-352093
ABSTRACT
The aim of this study was to explore application value of detecting platelet associated antibody and platelet membrane glycoprotein in the diagnosis and prognosis for immune thrombocytopenia. The platelet associated immunoglobulin (PAIg) and platelet membrane glycoprotein (CD41, CD61, GPIIb/IIIa) in 76 cases of immune thrombocytopenia and 30 healthy subjects were determined by FCM. The results showed that PAIg level in ITP patients included PAIgG (31.25 +/- 18.06)%, PAIgM (32.41 +/- 15.51)%, PAIgA (23.39 +/- 16.67)% which were remarkedly higher than in health control (10.48 +/- 5.05)%, (9.40 +/- 4.42)% and (7.23 +/- 3.61)% (P < 0.001). In patients with secondary immune thrombocytopenia (chronic aplastic anemia, SLE, Evans syndrome, liver cirrhosis hypersplenism, etc), PAIg level was higher than that in control group, while the platelet membrane glycoprotein in the blood of these patients was lower than that in control group. The level of PAIg decreased (P < 0.05) after treatment, but platelet membrane glycoprotein increased (P < 0.01). The result suggested that measurements for platelet membrane glycoprotein and platelet associated antibody by FCM were practical with high sensitivity, rapidity and simplicity used as a routine method in diagnosis and evaluation of the therapeutic effects in immune thrombocytopenia patients.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Trombocitopenia / Sangre / Plaquetas / Inmunoglobulinas / Glicoproteínas de Membrana Plaquetaria / Púrpura Trombocitopénica Idiopática / Complejo GPIIb-IIIa de Glicoproteína Plaquetaria / Glicoproteína IIb de Membrana Plaquetaria / Integrina beta3 / Diagnóstico Tipo de estudio: Estudio diagnóstico Límite: Adolescente / Adulto / Anciano / Niño / Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Experimental Hematology Año: 2004 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Trombocitopenia / Sangre / Plaquetas / Inmunoglobulinas / Glicoproteínas de Membrana Plaquetaria / Púrpura Trombocitopénica Idiopática / Complejo GPIIb-IIIa de Glicoproteína Plaquetaria / Glicoproteína IIb de Membrana Plaquetaria / Integrina beta3 / Diagnóstico Tipo de estudio: Estudio diagnóstico Límite: Adolescente / Adulto / Anciano / Niño / Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Experimental Hematology Año: 2004 Tipo del documento: Artículo