The influence of postburn administration of rhGH on the host inflammatory response / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 216-218, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-352283
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the changes in the systemic inflammatory response and T cell induced immunity after systemic administration of recombinant human growth hormone (rhGH) during early postburn stage.</p><p><b>METHODS</b>Forty Sprague-Dawley (SD) rats were randomly divided into three groups for the study. The rats in control group (C, n = 6) were only used for the determination of plasma levels of the cytokines, such as TNFalpha, IL-2, IL-6 and CD4(+) and CD8(+) cells. The SD rats in burn with rhGH treatment group (BT, n = 18) and burn without treatment group (B, n = 18) were inflicted with III degree scalding injury on the back. rhGH was injected subcutaneously on the abdomen of the rats in a dose of 6 IU/kg for 10 days in BT group. The blood samples were harvested from the rats in the two groups for the evaluation of the above indices.</p><p><b>RESULTS</b>The plasma levels of TNFalpha, IL-2, IL-6 and CD4(+) and CD8(+) cells were increased on the 3(rd) postburn day (PBD) and decreased on the 6(th) PBD in B group, while the CD4(+) and CD8(+) cells were increased significantly and the plasma levels of TNFalpha, IL-2, IL-6 decreased obviously on the 3(rd) PBD in BT group. And the plasma levels of IL-2 and IL-6 in BT group on the 6(th) PBD showed no difference from those in C group. But the plasma TNFalpha level in BT group was evidently higher than that in B and C group on the 6(th) PBD. Furthermore, the plasma levels of TNFalpha, IL-2 and IL-6 in BT group were still increased gradually on the 10(th) PBD, while the IL-2 and IL-6 levels were decreased obviously in B group, but the TNFalpha level was increased.</p><p><b>CONCLUSION</b>Systemic administration of rhGH during different states of stress exerted different effects on T cell induced immunity and systemic inflammatory response.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Cicatrización de Heridas
/
Sangre
/
Proteínas Recombinantes
/
Quemaduras
/
Linfocitos T CD4-Positivos
/
Interleucina-6
/
Interleucina-2
/
Factor de Necrosis Tumoral alfa
/
Ratas Sprague-Dawley
/
Linfocitos T CD8-positivos
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Burns
Año:
2003
Tipo del documento:
Artículo
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