Expression of MDR1 gene in cancer stem cells in breast cancer tissues of different molecular subtypes / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the association between MDR1 gene expression in breast cancer stem cells and the molecular subtypes of breast cancer tissue.</p><p><b>METHODS</b>According to ER, PR, Her-2 and CK5/14 expression profiles, 153 breast cancer specimens were divided into 5 molecular molecular subtypes, in which the expression of MDR1 was detected to analyze the relationship between MDR1 gene expression and the subtypes of breast cancer stem cells.</p><p><b>RESULTS</b>The expression of MDR1 in Luminal A subtype breast cancer was 0.26∓0.04, which showed no significant difference from that of Luminal B subtype (0.31∓0.03, P>0.05). Compared with these two subtypes, HER-2 (+) subtype breast cancer tissues showed a significantly higher MDR1 expression(0.56∓0.05, P<0.05). MDR1 expression in Basal-like subtype and Normal-like subtype breast cancers was comparable (0.98∓0.01 vs 0.90∓0.15, P<0.05), but both significantly higher than that in Luminal A and B subtypes and HER-2 (+) subtype (P<0.05).</p><p><b>CONCLUSION</b>The expression of MDR1 gene in cancer stem cells is related with the molecular subtypes of breast cancer tissue.</p>