The analysis of human immunodeficiency virus-1 subtypes in Yunnan province / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 892-894, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-352431
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the geographical distribution and risk factors of HIV-1 subtypes in Yunnan province.</p><p><b>METHODS</b>Blood samples from 1319 HIV positives were collected in Yunnan Province from 2001 to 2006. The nested polymerase chain reaction was used to amplify the gag (p24)-protease fragments from RNA extracted from plasma or sera. The sequences were used for subtype determination by phylogenetic tree analysis.</p><p><b>RESULTS</b>Among 1319 samples studied, the subtypes has been successfully obtained from 644 samples that were constituted of seven subtypes CRF08_BC, CRF07_BC, CRF07/08_BC, CRF01_AE, C, B' and URFB/C. C/CRF07_BC/CRF08_BC were distributed in the whole province, but CRF01_AE were mainly distributed in the boarding areas with Myanmar such as Dehong, Baoshan, Xishuangbanna and Puer. Moreover, injecting drugs users accounted for 61.6% (270/438) among C/CRF07_BC/CRF08_BC infections, while only 8.5% (15/177) among CRF01_AE infections.</p><p><b>CONCLUSION</b>Our data indicated that at least seven subtypes were identified in Yunnan province, the relationship between subtypes and transmission routes were analyzed, and the geographic difference of subtypes was also observed.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Virología
/
ADN Viral
/
Infecciones por VIH
/
China
/
VIH-1
/
Clasificación
/
Análisis de Secuencia de ADN
/
Genotipo
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Chinese Journal of Preventive Medicine
Año:
2008
Tipo del documento:
Artículo
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