Association of genetic polymorphisms in selenoprotein GPX1 and TXNRD2 with genetic susceptibility of gastric cancer / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 511-514, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-352453
ABSTRACT
<p><b>OBJECTIVE</b>This study examined whether the two polymorphisms of GPX1 (198Pro--> Leu) and TXNRD2 (370Lys-->Arg) contributed alone or in combination, to the risk of gastric cancer development.</p><p><b>METHODS</b>A total of 361 patients with gastric cancer and 363 cancer-free controls were recruited and their genotypes of the two polymorphisms were determined by polymerase chain reaction-based restrictive fragment length polymorphism (PCR-RFLP) method. Odds ratio (OR) and 95% confidence interval (CI) were computed using unconditional logistic regression model.</p><p><b>RESULTS</b>GPX1 and TXNRD2 polymorphisms individually were not associated with the risk of gastric cancer. Gene-gene interaction of GPX1 and TXNRD2 polymorphisms decreased the risk of gastric cancer. Carrying the protective genotype might decrease the risk at 62% (OR = 0.38, 95% CI = 0.26-0.55, P < 0.001) as compared with the risk genotype.</p><p><b>CONCLUSION</b>The GPX1 198 Pro/Pro and TXNRD2 370Arg/Arg genotypes might be associated with the genetic susceptibility of gastric cancer.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Gástricas
/
Estudios de Casos y Controles
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Alelos
/
Tiorredoxina Reductasa 2
/
Frecuencia de los Genes
/
Genética
/
Genotipo
/
Glutatión Peroxidasa
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Preventive Medicine
Año:
2008
Tipo del documento:
Artículo
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