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Effect of partial liquid ventilation on oleic acid-induced inflammatory responses in piglets / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 2088-2093, 2010.
Artículo en Inglés | WPRIM | ID: wpr-352507
ABSTRACT
<p><b>BACKGROUND</b>Pediatric patients are susceptible to lung injury. Acute lung injury (ALI) in children often results in a high mortality. Partial liquid ventilation (PLV) has been shown to markedly improve oxygenation and reduce histologic evidence of injury in a number of lung injury models. This study aimed to examine the hypothesis that PLV would attenuate the production of local and systemic cytokines in an immature piglet model of ALI induced by oleic acid (OA).</p><p><b>METHODS</b>Twelve Chinese immature piglets were induced to develop ALI by oleic acid. The animals were randomly assigned to two groups (n = 6) (1) conventional mechanical ventilation (MV) group and (2) PLV with FC-77 (10 ml/kg) group.</p><p><b>RESULTS</b>Compared with MV group, PLV group got better cardiopulmonary variables (P < 0.05). These variables included heart rate, mean blood pressure, blood pH, partial pressure of arterial oxygen (PaO2), PaO2/FiO2 and partial pressure of arterial carbon dioxide (PaCO2). Partial liquid ventilation reduced IL-1beta, IL-6, IL-10 and TNF-alpha both in plasma and tissue concentrations compared with MV group (P < 0.05).</p><p><b>CONCLUSIONS</b>Partial liquid ventilation provides protective effects against inflammatory responses in the lungs of oleic acid-induced immature piglets.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Respiración Artificial / Porcinos / Terapéutica / Distribución Aleatoria / Interleucina-6 / Factor de Necrosis Tumoral alfa / Interleucina-10 / Ácido Oléico / Ventilación Liquida / Usos Terapéuticos Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés Revista: Chinese Medical Journal Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Respiración Artificial / Porcinos / Terapéutica / Distribución Aleatoria / Interleucina-6 / Factor de Necrosis Tumoral alfa / Interleucina-10 / Ácido Oléico / Ventilación Liquida / Usos Terapéuticos Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés Revista: Chinese Medical Journal Año: 2010 Tipo del documento: Artículo