Clinicopathologic features of gastrointestinal tract involvement of anaplastic large cell lymphoma / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 228-233, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-352923
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinicopathological characteristics of gastrointestinal tract involvement of anaplastic large cell lymphoma (ALCL).</p><p><b>METHODS</b>The clinicopathological features of four patients with ALCL that involved gastrointestinal tract were retrospectively analyzed using immunohistochemical study, T-cell receptor gene rearrangement analysis, and evaluation for Epstein Barr virus infection status.</p><p><b>RESULTS</b>Most tumor cells in all these four cases are large and highly pleomorphic, and all four cases were classified as the common pattern ALCL. Tumor cells in all four tumors expressed CD30, and expressed at least one cytotoxic maker. Two patients were confirmed to be with anaplastic lymphoma kinase (ALK)-positive ALCL, and four patients were negative during in situ hybridization for Epstein-Barr virus-encoded RNA but showed clonal T-cell receptor gene rearrangement.</p><p><b>CONCLUSION</b>Gastrointestinal tract involvement of ALCL has the unique clinicopathological features.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Reordenamiento Génico de Linfocito T
/
Biomarcadores de Tumor
/
Estudios Retrospectivos
/
Linfoma Anaplásico de Células Grandes
/
Antígeno Ki-1
/
Infecciones por Virus de Epstein-Barr
/
Diagnóstico
/
Neoplasias Gastrointestinales
/
Metabolismo
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Acta Academiae Medicinae Sinicae
Año:
2012
Tipo del documento:
Artículo
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