DNA and RNA random amplification polymorphism in 5-flurocytosine-resistant strains of Candida albicans from revul-vaginal candidasis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 69-72, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-353246
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the DNA genome and RNA expression in 5-flurocytosine-resistant strains of Candida albicans from vaginal candidasis.</p><p><b>METHODS</b>Sixteen strains of Candida albicans were selected from clinically diagnosed revul-vaginal candidasis. Eight 5-flurocytosine-sensitive isolates and 8 resistant isolates were examined by France Media FUNGUS sensitive test. DNA genome was detected with random amplification polymorph DNA. RNA expression was detected with random amplification polymorph RNA method.</p><p><b>RESULTS</b>There were no distinct differences between 5-flurocytosine-sensitive and resistant Candida albicans in DNA genome, while RNA expression showed significant differences between 5-flurocytosine-resistant and sensitive strains.</p><p><b>CONCLUSION</b>Clinical 5-flurocytosine-resistant strains of Candida albicans from revul-vaginal candidasis may be related to phenotype changes.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Candida albicans
/
Candidiasis Vulvovaginal
/
ADN de Hongos
/
ARN de Hongos
/
Técnica del ADN Polimorfo Amplificado Aleatorio
/
Farmacorresistencia Fúngica
/
Flucitosina
/
Genética
/
Microbiología
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2005
Tipo del documento:
Artículo
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