Establishment of computer-based video-tracking conditioned place preference experiment system in mice / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 524-528, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-353268
ABSTRACT
<p><b>OBJECTIVE</b>To establish the computer-based video-tracking conditioned place preference (CPP) system in mice.</p><p><b>METHODS</b>The CPP system was composed of computer, camera, soundproof box, shuttle box and analytical software. The results of morphine-induced conditioned place preference were used to evaluate the experiment system. And the effect of morphine-induced locomotor activity in drug-paired compartment was studied in mice.</p><p><b>RESULTS</b>Low (1 mg/kg, i.p.), moderate (3 mg/kg, 5 mg/kg, i.p.) and high (10 mg/kg, i.p.) dose of morphine significantly prolonged the time mice spent in drug-paired compartment compared with saline, but there was no dose-response relation. Moderate and high dose of morphine significantly enhanced locomotor activity, among which 5 mg/kg and 10 mg/kg morphine induced behavior sensitization in drug-paired compartment during the conditioning sessions.</p><p><b>CONCLUSION</b>The computer-based video-tracking conditioned place preference experiment system in mice established successfully is reliable and stable.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fisiología
/
Psicología
/
Grabación en Video
/
Procesamiento Automatizado de Datos
/
Condicionamiento Psicológico
/
Modelos Animales
/
Ratones Endogámicos ICR
/
Morfina
/
Actividad Motora
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2004
Tipo del documento:
Artículo
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