Experimental induction of posterior vitreous detachment in rabbits with hyaluronidase and perfluoroethane (C2F6) / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 335-339, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-353310
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the experimental induction of posterior vitreous detachment (PVD) by intravitreous injection of hyaluronidase and perfluoroethane (C(2)F(6)).</p><p><b>METHODS</b>Fifteen rabbits (30 eyes) were divided into 3 experimental groups,the contralateral eyes in same animals served as the controls. Eyes in group A and B were received two vitreous injections of 15 IU of hyaluronidase at an interval of 5 d. The eyes in group C and all control eyes were injected with balanced salt solution (BSS). Seven days after injection, the experimental eyes in group A and C were received 0.5 ml of Fifteen rabbits (30 eyes) were divided into 3 experimental groups, the contralateral eyes in same animals served as the controls. Eyes in group A and B were received two vitreous injections of 15 IU of hyaluronidase at an interval of 5 d. The eyes in group C and all control eyes were injected with balanced salt solution (BSS). Seven days after injection,the experimental eyes in group A and C were received 0.5 ml of C(2)F(6) injection. The ocular and retinal signs were examined for 8 following weeks and then killed for histological examination.</p><p><b>RESULT</b>Five eyes in group A (100.0%) showed complete separation of the vitreous cortex from the retina (PVD), three eyes in group B(60.0%) showed partial PVD, and no PVD was detected in group C and all control eyes. On electroretinogram no significant difference was found in amplitude and latency of a-(or b-) wave in both experimental and control eyes, between before and after experiments. No evidence of ocular or retinal toxicity was revealed by light or scanning electronic microscopy in all eyes.</p><p><b>CONCLUSION</b>Vitreous injection of hyaluronidase combined with perfluoroethane, as a safety method, can induce posterior vitreous detachment without mechanical vitrectomy.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Cirugía General
/
Procedimientos Quirúrgicos Oftalmológicos
/
Cuerpo Vítreo
/
Desprendimiento del Vítreo
/
Electrorretinografía
/
Fluorocarburos
/
Hialuronoglucosaminidasa
/
Métodos
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2004
Tipo del documento:
Artículo
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