Synthesis of thienopyridine derivatives and its anti-platelet activity in vivo / 药学学报
Acta Pharmaceutica Sinica
;
(12): 70-74, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-353328
ABSTRACT
To explore novel ADP receptor inhibitors with anti-thrombotic activity, eighteen compounds were synthesized and their structures were confirmed by 1H NMR and MS. The results showed that the activity of compound C1 was superior to ticlopidine in platelet aggregation inhibition tests in vivo and worthy for further investigation. Compounds A4, B2, C4 and C7 possessed moderate platelet aggregation inhibitory activities.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Inhibidores de Agregación Plaquetaria
/
Estructura Molecular
/
Distribución Aleatoria
/
Química
/
Agregación Plaquetaria
/
Ratas Wistar
/
Tienopiridinas
/
Antagonistas del Receptor Purinérgico P2Y
Límite:
Animales
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2011
Tipo del documento:
Artículo
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