The role of ADME evaluation in translation research of innovative drug / 药学学报
Acta Pharmaceutica Sinica
;
(12): 19-29, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-353335
ABSTRACT
New Chemical Entities (NCEs) development is a systematic long-term project that involves multiple disciplines. The translation research will help to build an advanced R&D system from the basic laboratory research, preclinical studies and clinical evaluation to clinical application of drug, for the purpose of shortening the R&D cycle and accelerate the launch of new drugs. In new drug R&D and its clinical application, drug disposition (absorption, distribution, metabolism, excretion, ADME) properties are important criteria for assessing drug-likeness of candidates. ADME evaluation of NCEs plays an important role in the translation research throughout innovative drug R&D process. Therefore, ADME evaluation at the early stage of drug design and development will be helpful to improve the success rate and reduce costs, and further access to safe, effective drugs.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Transporte Biológico
/
Farmacocinética
/
Preparaciones Farmacéuticas
/
Distribución Tisular
/
Diseño de Fármacos
/
Química
/
Evaluación Preclínica de Medicamentos
/
Absorción
/
Investigación Biomédica Traslacional
/
Metabolismo
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2011
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS