G3BP: a promising target for cancer therapy / 药学学报
Acta Pharmaceutica Sinica
;
(12): 945-951, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-353400
ABSTRACT
G3BP (Ras-GTPase-activating protein SH3 domain binding protein), a protein which binds to RasGAP SH3 domain, belongs to RNA-binding protein family, implicating in the downstream of Ras signaling. G3BP harbors the activities of endoribonuclease and DNA helicase, and can induce stress granules formation. G3BP plays a general role in the signal pathways of cell proliferation, differentiation, apoptosis and RNA metabolism. It has been shown to be over-expressed in a number of human malignancies and has a close relationship with tumor invasion and metastasis. Given that it has been implicated in several pathways that are known to be involved in cancer biology, G3BP may provide a new target for cancer therapy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Fragmentos de Péptidos
/
Fosforilación
/
Datos de Secuencia Molecular
/
Transducción de Señal
/
Proteínas Portadoras
/
Sistemas de Liberación de Medicamentos
/
ADN Helicasas
/
Dominios Homologos src
/
ARN Helicasas
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2010
Tipo del documento:
Artículo
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