Preparation and characterization of oxaliplatin-loaded nanostructured lipid carriers / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1177-1182, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-353404
ABSTRACT
Oxaliplatin-loaded nanostuctured lipid carriers (OP-NLC) were prepared by ultrasonic emulsification method. And its optimal prescription was selected by orthogonal design. The laser light scattering technique, zeta potential analyzer, TEM, DSC, XRD and HPLC were employed to study the physicochemical parameters of OP-NLC, which displayed in terms of particle size, zeta potential, crystalline, drug loading and encapsulation efficiency. The results showed that OP-NLC had an average diameter of (111 +/- 20) nm, zeta potential of (-27.4 +/- 13.1) mV, encapsulation efficiency of (77.4 +/- 2.5) % and drug content of (0.8 +/- 1.5) mg mL(-1). TEM, DSC and XRD indicated that OP-NLC was spherical and the drug was dispersed as nanoparticles by means of non-crystalline. The in vitro release test showed that the drug could be sustained-released from NLC in buffer solution (pH 4.5) after a burst release in initial phase.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Compuestos Organoplatinos
/
Tamaño de la Partícula
/
Rastreo Diferencial de Calorimetría
/
Portadores de Fármacos
/
Química
/
Cromatografía Líquida de Alta Presión
/
Preparaciones de Acción Retardada
/
Microscopía Electrónica de Transmisión
/
Composición de Medicamentos
/
Nanopartículas
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2010
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS