In vitro absorption mechanism of strychnine and the transport interaction with liquiritin in Caco-2 cell monolayer model / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1160-1164, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-353407
ABSTRACT
To study the effect of liquiritin (Liq) on the transport of strychnine (Str) in Caco-2 cell monolayer model, the transport parameters of Str, such as apparent permeability coefficient (P app (B-->A) and P app (A-->B)) and cumulative transport amount (TRcum), were determined and comparatively analyzed when Str was used solely and co-used with Liq. The effect of drug concentrations, conveying times, P-glycoprotein (P-gp) inhibitor verapamil and conveying liquor pH values on the transport of Str were also investigated. The results indicated that the absorption of Str in Caco-2 cell monolayer model was well and the passive transference was the main intestinal absorption mechanism of Str in the Caco-2 monolayer model, along with the excretion action mediated by P-gp. Liq enhanced the absorption of Str. Meanwhile, conveying liquor pH value had significant influence on the excretion transport of Str.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Permeabilidad
/
Farmacología
/
Plantas Medicinales
/
Estricnina
/
Transporte Biológico
/
Farmacocinética
/
Verapamilo
/
Química
/
Miembro 1 de la Subfamilia B de Casetes de Unión a ATP
/
Células CACO-2
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2010
Tipo del documento:
Artículo
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