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Application of molecular diagnostic techniques in precision medicine of personalized treatment for colorectal cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery ; (12): 22-26, 2016.
Artículo en Chino | WPRIM | ID: wpr-353726
ABSTRACT
Precision medicine is to customize the treatment options for individual patient based on the personal genome information. Colorectal cancer (CRC) is one of the most common cancer worldwide. Molecular heterogeneity of CRC, which includes the MSI phenotype, hypermutation phenotype, and their relationship with clinical preferences, is believed to be one of the main factors responsible for the considerable variability in treatment response. The development of powerful next-generation sequencing (NGS) technologies allows us to further understand the biological behavior of colorectal cancer, and to analyze the prognosis and chemotherapeutic drug reactions by molecular diagnostic techniques, which can guide the clinical treatment. This paper will introduce the new findings in this field. Meanwhile we integrate the new progress of key pathways including EGFR, RAS, PI3K/AKT and VEGF, and the experience in selective patients through associated molecular diagnostic screening who gain better efficacy after target therapy. The technique for detecting circulating tumor DNA (ctDNA) is introduced here as well, which can identify patients with high risk for recurrence, and demonstrate the risk of chemotherapy resistance. Mechanism of tumor drug resistance may be revealed by dynamic observation of gene alteration during treatment.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fenotipo / Pronóstico / Recurrencia / Neoplasias Colorrectales / Selección de Paciente / Resistencia a Antineoplásicos / Fosfatidilinositol 3-Quinasas / Técnicas de Diagnóstico Molecular / Medicina de Precisión / Mutación Tipo de estudio: Estudio diagnóstico / Estudio pronóstico Límite: Humanos Idioma: Chino Revista: Chinese Journal of Gastrointestinal Surgery Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fenotipo / Pronóstico / Recurrencia / Neoplasias Colorrectales / Selección de Paciente / Resistencia a Antineoplásicos / Fosfatidilinositol 3-Quinasas / Técnicas de Diagnóstico Molecular / Medicina de Precisión / Mutación Tipo de estudio: Estudio diagnóstico / Estudio pronóstico Límite: Humanos Idioma: Chino Revista: Chinese Journal of Gastrointestinal Surgery Año: 2016 Tipo del documento: Artículo