Effect of Qingkailing injection (QKLI) on complement and RBL-2 H3 cells in virto / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1884-1888, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-354168
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Qingkailing injection (QKLI) on complement and RBL-2 H3 cells in virto.</p><p><b>METHOD</b>The mixture of human serums and QKLI were incubated for 30 min in vitro and then the content of SC5 b-9 in the mixture was determined by ELISA. RBL-2 H3 cells were cultured and treated by QKLI. Beta-heosaminidase release rate was measured by coloration method. The content of histamine in supernatant was tested by ELISA.</p><p><b>RESULT</b>The QKLI can reduce the content of SC5 b-9 (P<0.05) and promote the release of beta-heosaminidase and histamine significantly (P<0.05).</p><p><b>CONCLUSION</b>QKLI didn't induce the complement activation, but induced the release of beta-heosaminidase and histamine directly. Therefore, the clinical adverse reactions of QKLI in clinic may be pseudoallergy which had no relation with the activation of complement system.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Proteínas del Sistema Complemento
/
Medicamentos Herbarios Chinos
/
Degranulación de la Célula
/
Química
/
Química Farmacéutica
/
Secreciones Corporales
/
Línea Celular Tumoral
/
Hexosaminidasas
/
Liberación de Histamina
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2011
Tipo del documento:
Artículo
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