Therapeutic effects of saponins from Achyranthes bidentata in SHRsp / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the therapeutic effects of saponins from Achyranthes bidentata (SAB) in stroke-prone sponyaneously hypertension rats (SHRsp).</p><p><b>METHOD</b>Sixty SHRsp were randomly divided into five groups SAB 0.10, 0.20, 0.40 g x kg(-1), Huatuo Zaizao pill group (positive control group) 2.5 g x kg(-1) and pathologic group (n=10). SAB and Huatuo Zaizao pill were used through filing stomach everyday for 20 days, pathologic group was given distilled water. The effects of SAB on blood pressure, changes of nerve state, death rate, brain index and the pathologic changes of hippocampal neuron of SHRsp were observed.</p><p><b>RESULT</b>SAB could markedly decrease brain index, death rate of SHRsp after stroke. SAB could improve nerve state of SHRsp after stroke. Also SAB could prolong survival time and prevent pathologic change of hippocampal neuron of SHRsp after stroke.</p><p><b>CONCLUSION</b>SAB is advantageous of therapying the stroke in SHRsp.</p>