Receptor selection and B cell immune tolerance / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 374-376, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-354295
ABSTRACT
The immune system of mammalian has developed sophisticated mechanism to deal with diverse unknown antigens by random rearrangement of V, D and J antigen gene fragments. The immune self-tolerance is the mechanism to avoid self-destruction by the gene rearrangement generated autoreactive lymphocytes. Until recently it was believed that autoreactive lymphocytes are either deleted or rendered unable to respond by the supposed cell or clone selection mechanism. However, recent findings from a number of laboratories suggest instead of cell selection but receptor selection plays an essential role in immune self-tolerance. Receptor selection is carried out by secondary or nested rearrangement of antigen receptor gene fragments, and can occur at different stages of lymphocyte differentiation. Furthermore, secondary rearrangement of receptor gene also plays an important role in shaping immune response after the interaction of receptor with antigen by altering its specificity.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Enfermedades Autoinmunes
/
Genes de Inmunoglobulinas
/
Linfocitos B
/
Receptores de Antígenos de Linfocitos B
/
Reordenamiento Génico de Linfocito B
/
Autotolerancia
/
Alergia e Inmunología
/
Tolerancia Inmunológica
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2005
Tipo del documento:
Artículo
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