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The relationship between methylation of p16 INK 4/CDKN2 gene in promoter region and progress of squamous cell carcinoma of buccal mucosa / 中华口腔医学杂志
Chinese Journal of Stomatology ; (12): 297-298, 2006.
Artículo en Chino | WPRIM | ID: wpr-354392
ABSTRACT
<p><b>OBJECTIVE</b>To determine the correlation between methylation of p16 gene in promoter region and the carcinogenesis and progression of squamous cell carcinoma (SCC) of buccal mucosa.</p><p><b>METHODS</b>Methylation of pl6 gene in SCC and leukoplakia of buccal mucosa was investigated by MSP and pl6 protein was analyzed by Western blot.</p><p><b>RESULTS</b>The methylation of p16 gene was found in 15 of 30 cases SCC and 1 of 10 cases of leukoplakia of buccal mucosa (P < 0.05). Methylation of p16 gene in SCC of buccal mucosa was not related with age, sex, cell differentiation and clinical stage. But methylation of p16 in the cases with lymph node-metastasis was higher than that in the cases without lymph node-metastasis protein (P < 0.05). Meanwhile Methylation of p16 gene was positively correlated with no-expression of p16 protein (P < 0.01).</p><p><b>CONCLUSIONS</b>The methylation of p16 gene leaded to the inactivation of p16 gene and was related with the carcinogenesis and progress of SCC of buccal mucosa.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Leucoplasia Bucal / Neoplasias de la Boca / Carcinoma de Células Escamosas / Mejilla / Embriología / Regiones Promotoras Genéticas / Metilación de ADN / Genes p16 / Inhibidor p16 de la Quinasa Dependiente de Ciclina Límite: Humanos Idioma: Chino Revista: Chinese Journal of Stomatology Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Leucoplasia Bucal / Neoplasias de la Boca / Carcinoma de Células Escamosas / Mejilla / Embriología / Regiones Promotoras Genéticas / Metilación de ADN / Genes p16 / Inhibidor p16 de la Quinasa Dependiente de Ciclina Límite: Humanos Idioma: Chino Revista: Chinese Journal of Stomatology Año: 2006 Tipo del documento: Artículo